The G·U wobble base pair
نویسندگان
چکیده
منابع مشابه
Enol form of uracil in the GU"wobble"pair. NMR evidence
The idea of the enol form of nucleotides being responsible for the formation of some noncanonical pairs was put forward by Watson and Crick in their first paper on DNA structure [1]. In the context of this hypothesis, the GU pair may contain either the enol form of uracil and the keto form of guanine or the enol form of guanine and the keto form of uracil. Later, in 1966, Francis Crick proposed...
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N-Nitrosation of glycine and its derivatives generates potent alkylating agents that can lead to the formation of O(6)-carboxymethylguanine (O(6)-CMG) in DNA. O(6)-CMG has been identified in DNA derived from human colon tissue and its occurrence has been linked to diets high in red and processed meats, implying an association with the induction of colorectal cancer. By analogy to O(6)-methylgua...
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The HDV ribozyme's folding pathway is, by far, the most complex folding pathway elucidated to date for a small ribozyme. It includes 6 different steps that have been shown to occur before the chemical cleavage. It is likely that other steps remain to be discovered. One of the most critical of these unknown steps is the formation of the trans Watson-Crick GU base pair within loop III. The U(23) ...
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G.U wobble base pairs are the most common and highly conserved non-Watson-Crick base pairs in RNA. Previous surface maps imply uniformly negative electrostatic potential at the major groove of G.U wobble base pairs embedded in RNA helices, suitable for entrapment of cationic ligands. In this work, we have used a Poisson-Boltzmann approach to gain a more detailed and accurate characterization of...
متن کاملDNA deformability at the base pair level.
A complete set of harmonic force constants describing the DNA deformation energetics at the base pair level was obtained using unrestrained atomic-resolution molecular dynamics simulations of selected duplex oligonucleotides and subsequent analysis of structural fluctuations from the simulated trajectories. The deformation was described by the six base pair conformational parameters (buckle, pr...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2000
ISSN: 1469-221X,1469-3178
DOI: 10.1093/embo-reports/kvd001